Search results for "P2Y12 receptor"

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Reorganization of platelet membrane sphingomyelins by adenosine diphosphate and ticagrelor

2018

IF 2.766 (2017); International audience; Platelets are major targets for the treatment of thrombo-embolic disorders. Their plasma membrane contains specialized microdomains enriched in sphingomyelins and free cholesterol including membrane receptors. P2Y12 receptors need to be situated in these domains to be able to conduct activation signaling by adenosine diphosphate (ADP). We studied the impact of ticagrelor, a P2Y12 antagonist, and ADP on the composition and distribution of sphingomyelins in detergent-resistant membrane (DRM) of platelet membranes. Platelets were obtained from healthy donors. DRMs of platelet membranes were isolated in 4 experimental groups: control; ADP, with platelets…

0301 basic medicineTicagrelorStimulation030204 cardiovascular system & hematologyBiochemistry03 medical and health scienceschemistry.chemical_compound0302 clinical medicineP2Y12Cell surface receptordetergent-resistant membranemedicinePlateletMolecular BiologyTriton X-100Cell MembraneOrganic ChemistrycholesterolCell Biology[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismSphingomyelinsAdenosine DiphosphateAdenosine diphosphate030104 developmental biologyMembranechemistryBiophysicsP2Y12 receptorSphingomyelinTicagrelormedicine.drug

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